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Table 1 Gene Ontology analysis and KEGG pathway analysis of KRAS isoform-expressing Colo741 cell clones.

From: Gene expression deregulation by KRAS G12D and G12V in a BRAF V600E context

System Gene Category – Term

Count

%

P-Value

Genes

KRAS G 12V Vs KRAS WT

GO biological process

Cell cycle arrest

6

6.7

5.50E-05

DDIT3, DHCR24, GADD45A, IL8, PPP1R15A, SESN2

Apoptosis

13

14.6

3.90E-04

ANXA1, APOE, GADD45A, IFIH1, IL24, DDIT3, DDIT4, DHCR24, PMAIP1, PPP1R15A, SEMA6A, TNFRSF19, TRIB3

KEGG pathway

Nitrogen metabolism

3

3.4

1.50E-02

ASNS, CTH, GLS

KRAS G 12D Vs KRAS WT

GO biological process

Cellular component organization and biogenesis

12

27.3

5.10E-02

CRYAB, EHD2, FHOD1, HIST1H1A, HSPB1, LIN7C, MAP3K11, PCDHB5, PCDHB16, SEMA6A, SLC7A11, SMCHD1

KRAS G 12D Vs KRAS G 12V

GO biological process

Immune system process

14

32.6

3.50E-07

BST2, CDK6, IFITM3, IFIT1, IFI27, IFI44, IL8, IL24, MICA, OAS1, OAS2, OAS3, SYK, S100B

Sterol metabolic process

6

14

1.10E-06

APOE, FDFT1, HMGCR, HMGCS1, IDI1, SC4MOL

KEGG pathway

Biosynthesis of steroids

4

9.2

5.70E-05

FDFT1, IDI1, HMGCR, SC4MOL

  1. Gene name symbols used are those approved by the Human Genome Organisation Gene Nomenclature Committee http://www.genenames.org/.
  2. Non-redundant functional categories, number of genes contained within each category, percentages ranked by the degree of over-representation in the category as determined by EASE (P-value) and gene members found to be modulated by the KRAS isoforms are shown. Redundant categories with similar gene members were removed to yield a single representative category.
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Molecular Cancer

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