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Table 1 Gene promoter methylation and microsatellite instability

From: Gene methylation profiles of normal mucosa, and benign and malignant colorectal tumors identify early onset markers

  ADAMTS1 CDKN2A CRABP1 HOXA9 MAL MGMT MLH1 NR3C1 RUNX3 SCGB3A1
  M U M U M U M U M U M U M U M U M U M U
Sample type                     
N1 0 21 0 21 0 21 4 17 1 20 2 19 0 21 0 21 0 1 1 20
N2 1 17 2 16 0 18 7 11 2 16 7 10 1 17 0 18 0 1 1 17
Adenoma 23 40 10 53 7 53 22 40 45 18 23 39 0 63 2 61 4 4 4 59
Carcinomas 36 15 17 35 25 25 12 38 41 9 21 31 11 41 13 37 16 9 9 40
MSI status                     
Carcinomas                     
MSI 19 8 10 17 22 5 7 20 21 6 11 16 11 16 12 15 16 8 8 18
MSS 17 7 7 18 3 20 5 18 20 2 10 15 0 25 1 22 0 1 1 22
P value NS NS <0.0001 NS NS NS <0.0001 0.001 <0.0001 0.026
  1. Abbreviations: M, methylated samples; U, unmethylated samples; NS, not significant; N1: non-cancerous normal samples; N2: normal samples from cancer patients. MSI status data is listed for the individual polyp. In some cases a patient may have several polyps.