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Figure 1 | Molecular Cancer

Figure 1

From: Elevated expression of p53 gain-of-function mutation R175H in endometrial cancer cells can increase the invasive phenotypes by activation of the EGFR/PI3K/AKT pathway

Figure 1

Expression of p53-R175H is associated with enhanced invasion and migration in KLE cells. (A) Western blot analysis showing p53 expression of p53-R175H in KLE cells after they had been transfected with a vector containing p53-R175H construct (R175H). Untransfected KLE cells (UT) and cells transfected with empty vector alone (Vector) served as the control. (B) Invasive ability of UT, R175H and Vector cells through the Matrigel-transwell membranes after 24 h of incubation. An asterisk indicates P < 0.05. UT and Vector cells served as the control. (C) Migratory property of UT, R175H and Vector cells through the transwell membranes after 6 h of incubation. An asterisk indicates P < 0.05. UT and Vector cells served as the control.

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Molecular Cancer

ISSN: 1476-4598