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Figure 5 | Molecular Cancer

Figure 5

From: Overexpression of RRM2 decreases thrombspondin-1 and increases VEGF production in human cancer cells in vitro and in vivo: implication of RRM2 in angiogenesis

Figure 5

Overexpression of RRM2 promoted the growth of KB-M2-D in vivo. (A) Typical RT-CES traces described that KB and KB-M2-D proliferated in an equal rate. CI was recorded every half hour. Each trace for each cell was an average of 4 replicates. (B) Tumor growth curves showed that RRM2 significantly promoted KB-M2-D in vivo growth. (C) Overexpression of RRM2 increased tumor xenografts size of KB-M2-D at the end of experiment. (D) q-RT-PCR analysis confirmed that RRM2, VEGF and TSP-1 mRNA was significantly different in KB-V and KB-M2 xenografts. *p < 0.05; **p < 0.01, compared with Kb-V. Data expressed was the mean ± SD of 12 mice of two independent experiments.

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Molecular Cancer

ISSN: 1476-4598