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Figure 3 | Molecular Cancer

Figure 3

From: Sorafenib blocks tumour growth, angiogenesis and metastatic potential in preclinical models of osteosarcoma through a mechanism potentially involving the inhibition of ERK1/2, MCL-1 and ezrin pathways

Figure 3

Sorafenib induces down-regulation of P-ERK 1/2 (A), MCL-1 (B) and P-ERM (C) on U2OS. Effect on P-ERM is independent from PDGFR, C-KIT and ERK pathways (D). Cells were cultured for 24 hours with escalating doses (5, 10, 20 μM) of sorafenib, 10 μM STI571, 10 μM UO126 or left untreated. After protein extraction P-ERK 1/2 (A), MCL-1, (B), P-ERM (C and D) immunoblotting was carried out.

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Molecular Cancer

ISSN: 1476-4598