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Figure 2 | Molecular Cancer

Figure 2

From: Lack of functional and expression homology between human and mouse aldo-keto reductase 1C enzymes: implications for modelling human cancers

Figure 2

Phylogeny of the AKR1C subfamily. A. phylogenetic tree showing the relationship between the 23 known AKR1C proteins. Protein sequences available at the AKR homepage http://www.med.upenn.edu/akr/ were aligned using ClustalW and a tree generated using TreeView X. Human AKR1C isoforms cluster closely together suggesting an early common ancestor while murine isoforms have higher diversity. B. Position of AKR1C genes in chromosome reflects phylogenetic relationships. To scale representation of murine (chromosome 13) and human (chromosome 10) AKR1C gene clusters. Grey boxes represent individual genes.

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Molecular Cancer

ISSN: 1476-4598