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Figure 5 | Molecular Cancer

Figure 5

From: Inhibition of p38 MAP kinase pathway induces apoptosis and prevents Epstein Barr virus reactivation in Raji cells exposed to lytic cycle inducing compounds

Figure 5

EBV activation in the presence of inhibitors of signal transduction pathways. Raji cells were treated as described in Fig. 4 A. (A) Fixed cells were stained for immunofluorescence analysis with FITC-labelled antibodies specific for EBV early antigens: a) no inhibitor; b), c), d), e), f) plus inhibitor of p38, ERK, JNK, PI3K or NFkB, respectively; (B) Raji cells were exposed to EBV activators in the absence (I) or in the presence (I+SB) of p38 inhibitor. At 48 hours, cell extracts were resolved onto a 10% acrylamide gel by SDS-PAGE, blotted and probed with BZLF1 or BFRF1 antibodies. Hybridization with GAPDH antibodies was used as loading control. Specific signal were visualized by ECL.

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Molecular Cancer

ISSN: 1476-4598