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Figure 4 | Molecular Cancer

Figure 4

From: δ-Catenin promotes prostate cancer cell growth and progression by altering cell cycle and survival gene profiles

Figure 4

δ-Catenin expression promotes the entry of mitosis. A. Mitotic index of cells expressing vector alone as a control and cells overexpressing δ-catenin. Mitotic index is given as the percentage of cells entering mitosis determined by Hoechst staining. Insert: mitotic cells (arrows) showing strong Hoechst staining. B. Immunofluorescent light microscopy showing increased mitotic activity in δ-catenin expressing cells (c and d) in comparison to control vector transfected cells (a and b). Mitotic activity is determined as the number of GFP positive, transfected cells (a and c) intensely reactive with anti-phosphorylated histone H3 (p-Histone H3, b and d). Arrows: examples of GFP positive, transfected cells immunoreactive for phosphorylated histone H3. Bar, 100 μm; Bar in the insert, 5 μm.

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Molecular Cancer

ISSN: 1476-4598