Figure 5
From: CHK1 inhibition as a strategy for targeting fanconi anemia (FA) DNA repair pathway deficient tumors
FANCD2 depleted Zebra Fish embryos are selectively sensitive to Gö6976. A graphical representation of zebrafish embryo viability following depletion of FANCD2 using an increasing concentration of a specific morpholino and treatment with Gö6976 (bars 2, 4, 6, 8, 10 and 12) or DMSO control (bars 1, 3, 5, 7, 9 and 11). Representative photographs of FANCD2 depleted embryos 24 hrs after Gö6976 treatment are shown. Gö6976 was used at a concentration of 0.5 uM.