Figure 3
From: Heme oxygenase-1 and its metabolites affect pancreatic tumor growth in vivo
Inhibition of HO-1 activity leads to increased susceptibility to chemotherapy in vitro. Cell viability was assessed 72 h after application of gemcitabine via MTT assay. (3A) Under gemcitabine treatment (LD50 dose) application of ZnPP revealed a dose dependent growth inhibition of PANC-1 cancer cells, whereas application of CoPP had no significant effect on cell proliferation. (3B) In S2-013 cell line implementation of CoPP led to increased cell proliferation, whereas ZnPP had no significant effect.