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Table 4 Linear correlation for total or 13C-labeled concentrations between pairs of glycolytic- and Krebs cycle-derived metabolites in human lung tissuesA

From: Altered regulation of metabolic pathways in human lung cancer discerned by 13C stable isotope-resolved metabolomics (SIRM)

 

R2

PlotsB

Non-cancerous

Cancer

[Ala] versus [succinate]

0.025

0.761

[13C-Ala] versus [13C-succinate]

0.483

0.792

[lactate] versus [succinate]

0.056

0.395

[13C-lactate] versus [13C-succinate]

0.412

0.374

[Glu] versus [succinate]

0.018

0.343

[13C-Glu] versus [13C-succinate]

0.072

0.912

[citrate] versus [succinate]

0.061

0.133

[13C-citrate] versus [13C-succinate]

0.069

0.789

  1. A R2 for the linear regression fit was calculated using Excel for patients #6–10 (n = 5).
  2. B Obtained from GC-MS analysis; [metabolite]: total concentration in μmole/g dry weight of metabolite; [13C-metabolite]: μmole/g dry weight of 13C-labeled metabolites
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Molecular Cancer

ISSN: 1476-4598