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Table 1 Oncolytic activity of ReoT3D in 9 NSCLC cell lines included in the NCI-60 cell line panel

From: Synergistic antitumor activity of oncolytic reovirus and chemotherapeutic agents in non-small cell lung cancer cells

NSCLC Cell Line

ED50 (log10 pfu/cell: mean ± SD)

NCI-H460*

2.68 ± 0.25

A549/ATCC*

2.51 ± 0.27

HOP-62*

2.56 ± 0.19

NCI-H322M

> 3.30

NCI-H226

> 3.30

EKVX

2.47 ± 0.34

NCI-H23*

2.47 ± 0.15

NCI-H522

1.46 ± 0.12

HOP-92

1.96 ± 0.27

  1. ED50: 50% effective dose defined by the initial MOI (pfu/cell) to achieve 50% cell death in 48 hours after infection. Shown are mean ± SD from 3 independent experiments. *Asterisk denotes cell lines with ras gene mutation. Abbreviations: ReoT3D, reovirus type 3 Dearing; NSCLC, non-small cell lung cancer; MOI, multiplicity of infection; pfu, plaque forming units.
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Molecular Cancer

ISSN: 1476-4598