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Table 1 Clinicopathological characteristics of the sporadic neoplasms studied and BRCA1 protein expression.

From: Methylation and protein expression of DNA repair genes: association with chemotherapy exposure and survival in sporadic ovarian and peritoneal carcinomas

BRCA1 Protein Expression
  All Cases Low Intermediate Normal p value
Primary site      
Ovarian 107 (93%) 39 27 41 p = 0.05
Peritoneal 8 (7%) 0 3 5  
Grade      
Grade 1 6 (5%) 3 2 1  
Grade 2 16 (16%) 5 3 8 NS
Grade 3 93 (79%) 31 25 37  
Histology      
Serous 81 (70%) 28 24 29 NS
Endometrioid 11 (10%) 4 2 5  
Carcinoma NOS 12 (10%) 3 3 6  
MMMT 4 (3%) 1 1 2  
Clear Cell 1 (1%) 0 0 1  
Mucinous 3(3%) 1 0 2  
Other* 3 (3%) 2 0 1  
Stage      
I 11 (10%) 2 1 8 p = 0.03
II 4 (3%) 3 0 1  
III 83 (72%) 28 26 29  
IV 17 (15%) 6 3 8  
Cytoreduction      
Optimal (< 1 cm) 73 24 18 31 NS
Suboptimal 36 14 9 13  
Not Available 6 1 3 2  
Total 116 39 (36%) 30 (26%) 46 (38%)  
  1. * Other histologies included one small cell, one transitional cell carcinoma and one carcinoma with focal giant cells.