Skip to main content

Table 1 Clinicopathological characteristics of the sporadic neoplasms studied and BRCA1 protein expression.

From: Methylation and protein expression of DNA repair genes: association with chemotherapy exposure and survival in sporadic ovarian and peritoneal carcinomas

BRCA1 Protein Expression

 

All Cases

Low

Intermediate

Normal

p value

Primary site

     

Ovarian

107 (93%)

39

27

41

p = 0.05

Peritoneal

8 (7%)

0

3

5

 

Grade

     

Grade 1

6 (5%)

3

2

1

 

Grade 2

16 (16%)

5

3

8

NS

Grade 3

93 (79%)

31

25

37

 

Histology

     

Serous

81 (70%)

28

24

29

NS

Endometrioid

11 (10%)

4

2

5

 

Carcinoma NOS

12 (10%)

3

3

6

 

MMMT

4 (3%)

1

1

2

 

Clear Cell

1 (1%)

0

0

1

 

Mucinous

3(3%)

1

0

2

 

Other*

3 (3%)

2

0

1

 

Stage

     

I

11 (10%)

2

1

8

p = 0.03

II

4 (3%)

3

0

1

 

III

83 (72%)

28

26

29

 

IV

17 (15%)

6

3

8

 

Cytoreduction

     

Optimal (< 1 cm)

73

24

18

31

NS

Suboptimal

36

14

9

13

 

Not Available

6

1

3

2

 

Total

116

39 (36%)

30 (26%)

46 (38%)

 
  1. * Other histologies included one small cell, one transitional cell carcinoma and one carcinoma with focal giant cells.
Back to article page

Molecular Cancer

ISSN: 1476-4598