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Table 4 p53 mutations and BRCA1 protein level in primary sporadic ovarian carcinomas

From: Methylation and protein expression of DNA repair genes: association with chemotherapy exposure and survival in sporadic ovarian and peritoneal carcinomas

  P53 Mutations
BRCA1 protein Expression Total Tested Missense
N (%)
Null
N (%)
Total P53 mutations
Low 28 10 (36%) 5 (18%) 15 (54%)
Intermediate 18 8 (44%) 2 (11%) 10 (56%)
Normal 33 6(18%) 2 (6%) 8 (24%)*
Total 79 24 (30%) 9 (11%) 33 (42%)
  1. *p = 0.01 for difference in p53 mutation frequency for cases with normal versus reduction or loss of BRCA1 protein.