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Table 4 p53 mutations and BRCA1 protein level in primary sporadic ovarian carcinomas

From: Methylation and protein expression of DNA repair genes: association with chemotherapy exposure and survival in sporadic ovarian and peritoneal carcinomas

 

P53 Mutations

BRCA1 protein Expression

Total Tested

Missense

N (%)

Null

N (%)

Total P53 mutations

Low

28

10 (36%)

5 (18%)

15 (54%)

Intermediate

18

8 (44%)

2 (11%)

10 (56%)

Normal

33

6(18%)

2 (6%)

8 (24%)*

Total

79

24 (30%)

9 (11%)

33 (42%)

  1. *p = 0.01 for difference in p53 mutation frequency for cases with normal versus reduction or loss of BRCA1 protein.
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Molecular Cancer

ISSN: 1476-4598