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Table 5 Deregulated pathways in canine OS pertaining to aggressive phenotype

From: Gene expression profiling of canine osteosarcoma reveals genes associated with short and long survival times

Reference Present study on canine osa Srivastava et al., 2006 Rajkumar, T. et al., 2008 Srivastava et al., 2006
Study approach poor survival associated profile high metastatic profile drug resistant profile osteogenic tumor profile
Samples used 32 primary tumors human osa cell lines cell line resistant to doxorubicin 10 tumors and 8 normal bones
Total differential expressed genes 1426 1999 485 194
Total Mapped IDs on PANTHER® 533 1185 295 159
Huntington disease 12  
Wnt signaling pathway 10
Chemokine/cytokine signaling pathway 8
Integrin signalling pathway 7  
Parkinson disease 6  
Ubiquitin proteasome pathway 6   
Alzheimer disease-presenilin pathway 5
Cadherin signaling pathway 5   
Endothelin signaling pathway 5    
Glycolysis 5    
Heterotrimeric G-protein signaling pathway 4   
Angiogenesis 3   
Cytoskeletal regulation by Rho GTPase 3   
EGF receptor signaling pathway 3   
FGF signaling pathway 3
p53 pathway 3   
PDGF signaling pathway 3
T cell activation 3  
TGF-beta signaling pathway 3  
Androgen/estrogene/progesterone biosynthesis 2    
Apoptosis signaling pathway 2
B cell activation 2    
Hedgehog signaling pathway 2    
Hypoxia response via HIF activation 2    
Interferon-gamma signaling pathway 2    
Interleukin signaling pathway 2
Oxidative stress response 2    
p53 pathway feedback loops 2 2   
PI3 kinase pathway 2  
Ras Pathway 2  
  1. Comparison of the top 20 pathways from 3 published human OS studies revealed 7 pathways (in bold letters) that are commonly deregulated in both human and canine OS. (▲: Common pathway hits found across different gene sets published for human OS to the present study in canine)