The rapamycin-regulated gene expression signature determines prognosis for breast cancer

Table 2 Cox multivariate regression analysis of survival according to clinical factors in the primary breast cancer data sets used.

	Miller et al. [27]			Wang et al. [28]			van 't Veer et al. [29]
Factor	HR	95% CI	P	HR	95% CI	P	HR	95% CI	P
RMI	0.03^a	0.00-0.69	0.029	0.27	0.10-0.71	0.008	0.23	NS	0.28
LN status (negative versus positive)	2.74	1.50-5.01	0.001
Tumor size^b	1.03	1.01-1.06	0.015
Age^b	1.01	0.99-1.03	NS
Grade (low [1 or 2] versus high 3)	1.43	0.90-2.26	NS
ER status (negative versus positive)	1.44	0.60-3.48	NS	1.07	0.69-1.65	NS	0.57	0.32-1.03	NS

Clinical data and the RMI with relative risk (hazards ratio), confidence interval, and P value were fitted to each of the clinical factors.
^aA coefficient of 0.03 means that the model gives a 97% decrease of the predicted hazard for an increase of 1 unit of RMI.
^bThere was no stratification of the variables, actual values were used in analysis.
HR, hazards ratio; CI, confidence interval; LN, lymph node; NS, not significant; ER, estrogen receptor.

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