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Table 3 List of anti-tumorigenic and pro-tumorigenic molecules modulated by introduction of TUSC2 in H2595 MPM cell line (expression array data).

From: Mechanisms of FUS1/TUSC2 deficiency in mesothelioma and its tumorigenic transcriptional effects

Anti-tumorigenic molecules
up-regulated by TUSC2
Fold
change
Pro-tumorigenic molecules
suppressed by TUSC2
Fold change
ALDH6A1, aldehyde dehydrogenase 6 family +2.5 ATF3, activating transcription factor 3 -2.7
APOL6, apolipoprotein L, 6 +2.0 CD24, CD24 molecule -3.1
BCL2L11, BCL2-like 11 (apoptosis facilitator) +2.0 CD274, CD274 antigen; programmed cell death 1 ligand 1 -6.2
CCDC98, coiled-coil domain containing 98 +2.3 CTGF, connective tissue growth factor -2.0
CCNG2, cyclin G2 +2.5 EFNB2, ephrin-B2 -2.0
EGR1, early growth response 1 +2.4 GPR87, G protein-coupled receptor 87 -2.3
EXT1, exostoses (multiple) 1 +2.1 ELK4, ETS-domain protein (SRF accessory protein 1) -2.2
FBXO4, F-box protein 4 +2.1 JUN, jun oncogene -2.5
FOXN3, forkhead box N3 +2.6 IL11, interleukin 11 -3.9
GAS1, growth arrest-specific 1 +2.1 LOX, lysyl oxidase -3.0
MCC, mutated in colorectal cancers +2.1 MALAT1, metastasis associated lung adenocarcinoma transcript 1 -2.5
MLL5, myeloid/lymphoid or mixed-lineage leukemia 5 +2.5 MIHG1, microRNA host gene -2.6
NME5, non-metastatic cells 5 +2.4 PLAU, plasminogen activator, urokinase -3.2
RARRES1, retinoic acid receptor responder (tazarotene induced) 1 +4.1 PLAUR, plasminogen activator, urokinase receptor -2.1
RARRES3, retinoic acid receptor responder (tazarotene induced) 3 +2.8 RGS4, regulator of G-protein signaling 4 -4.3
SELENBP1, selenium binding protein 1 +2.1 SET, SET translocation (myeloid leukemia-associated) -2.2
SIDT2, SID1 transmembrane family, member 2 +2.3 SKIL, SKI-like oncogene -2.3
SAMD9L, sterile alpha motif domain containing 9-like +2.0 THBS1, thrombospondin 1 -2.5
TNS1, tensin 1 +2.5 B4GALT1, UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase -2.5
WFDC2, WAP four-disulfide core domain 2 +3.5 ETS1, v-ets erythroblastosis virus E26 oncogene -2.3
WSB1, WD repeat and SOCS box-containing 1 +2.0