From: Mechanisms of FUS1/TUSC2 deficiency in mesothelioma and its tumorigenic transcriptional effects
Anti-tumorigenic molecules up-regulated by TUSC2 | Fold change | Pro-tumorigenic molecules suppressed by TUSC2 | Fold change |
---|---|---|---|
ALDH6A1, aldehyde dehydrogenase 6 family | +2.5 | ATF3, activating transcription factor 3 | -2.7 |
APOL6, apolipoprotein L, 6 | +2.0 | CD24, CD24 molecule | -3.1 |
BCL2L11, BCL2-like 11 (apoptosis facilitator) | +2.0 | CD274, CD274 antigen; programmed cell death 1 ligand 1 | -6.2 |
CCDC98, coiled-coil domain containing 98 | +2.3 | CTGF, connective tissue growth factor | -2.0 |
CCNG2, cyclin G2 | +2.5 | EFNB2, ephrin-B2 | -2.0 |
EGR1, early growth response 1 | +2.4 | GPR87, G protein-coupled receptor 87 | -2.3 |
EXT1, exostoses (multiple) 1 | +2.1 | ELK4, ETS-domain protein (SRF accessory protein 1) | -2.2 |
FBXO4, F-box protein 4 | +2.1 | JUN, jun oncogene | -2.5 |
FOXN3, forkhead box N3 | +2.6 | IL11, interleukin 11 | -3.9 |
GAS1, growth arrest-specific 1 | +2.1 | LOX, lysyl oxidase | -3.0 |
MCC, mutated in colorectal cancers | +2.1 | MALAT1, metastasis associated lung adenocarcinoma transcript 1 | -2.5 |
MLL5, myeloid/lymphoid or mixed-lineage leukemia 5 | +2.5 | MIHG1, microRNA host gene | -2.6 |
NME5, non-metastatic cells 5 | +2.4 | PLAU, plasminogen activator, urokinase | -3.2 |
RARRES1, retinoic acid receptor responder (tazarotene induced) 1 | +4.1 | PLAUR, plasminogen activator, urokinase receptor | -2.1 |
RARRES3, retinoic acid receptor responder (tazarotene induced) 3 | +2.8 | RGS4, regulator of G-protein signaling 4 | -4.3 |
SELENBP1, selenium binding protein 1 | +2.1 | SET, SET translocation (myeloid leukemia-associated) | -2.2 |
SIDT2, SID1 transmembrane family, member 2 | +2.3 | SKIL, SKI-like oncogene | -2.3 |
SAMD9L, sterile alpha motif domain containing 9-like | +2.0 | THBS1, thrombospondin 1 | -2.5 |
TNS1, tensin 1 | +2.5 | B4GALT1, UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase | -2.5 |
WFDC2, WAP four-disulfide core domain 2 | +3.5 | ETS1, v-ets erythroblastosis virus E26 oncogene | -2.3 |
WSB1, WD repeat and SOCS box-containing 1 | +2.0 | Â | Â |