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Table 3 List of anti-tumorigenic and pro-tumorigenic molecules modulated by introduction of TUSC2 in H2595 MPM cell line (expression array data).

From: Mechanisms of FUS1/TUSC2 deficiency in mesothelioma and its tumorigenic transcriptional effects

Anti-tumorigenic molecules

up-regulated by TUSC2

Fold

change

Pro-tumorigenic molecules

suppressed by TUSC2

Fold change

ALDH6A1, aldehyde dehydrogenase 6 family

+2.5

ATF3, activating transcription factor 3

-2.7

APOL6, apolipoprotein L, 6

+2.0

CD24, CD24 molecule

-3.1

BCL2L11, BCL2-like 11 (apoptosis facilitator)

+2.0

CD274, CD274 antigen; programmed cell death 1 ligand 1

-6.2

CCDC98, coiled-coil domain containing 98

+2.3

CTGF, connective tissue growth factor

-2.0

CCNG2, cyclin G2

+2.5

EFNB2, ephrin-B2

-2.0

EGR1, early growth response 1

+2.4

GPR87, G protein-coupled receptor 87

-2.3

EXT1, exostoses (multiple) 1

+2.1

ELK4, ETS-domain protein (SRF accessory protein 1)

-2.2

FBXO4, F-box protein 4

+2.1

JUN, jun oncogene

-2.5

FOXN3, forkhead box N3

+2.6

IL11, interleukin 11

-3.9

GAS1, growth arrest-specific 1

+2.1

LOX, lysyl oxidase

-3.0

MCC, mutated in colorectal cancers

+2.1

MALAT1, metastasis associated lung adenocarcinoma transcript 1

-2.5

MLL5, myeloid/lymphoid or mixed-lineage leukemia 5

+2.5

MIHG1, microRNA host gene

-2.6

NME5, non-metastatic cells 5

+2.4

PLAU, plasminogen activator, urokinase

-3.2

RARRES1, retinoic acid receptor responder (tazarotene induced) 1

+4.1

PLAUR, plasminogen activator, urokinase receptor

-2.1

RARRES3, retinoic acid receptor responder (tazarotene induced) 3

+2.8

RGS4, regulator of G-protein signaling 4

-4.3

SELENBP1, selenium binding protein 1

+2.1

SET, SET translocation (myeloid leukemia-associated)

-2.2

SIDT2, SID1 transmembrane family, member 2

+2.3

SKIL, SKI-like oncogene

-2.3

SAMD9L, sterile alpha motif domain containing 9-like

+2.0

THBS1, thrombospondin 1

-2.5

TNS1, tensin 1

+2.5

B4GALT1, UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase

-2.5

WFDC2, WAP four-disulfide core domain 2

+3.5

ETS1, v-ets erythroblastosis virus E26 oncogene

-2.3

WSB1, WD repeat and SOCS box-containing 1

+2.0

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