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Figure 7 | Molecular Cancer

Figure 7

From: Targeting EGFR with photodynamic therapy in combination with Erbitux enhances in vivo bladder tumor response

Figure 7

The effect of EGFR inhibition on target genes cyclin-D1 and c-myc was evaluated at the RNA level. Cyclin D1 is an important regulator of G1 to S-phase transition and overexpression of cyclin D1 has been linked to the development and progression of cancer. c-Myc is activated in a variety of tumor cells and plays an important role in cellular proliferation, differentiation, apoptosis and cell cycle progression. Downregulation of cyclin-D1 and c-myc was observed in the tumors treated with PDT and Erbitux (p < 0.05) when compared with the other groups.

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