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Figure 1 | Molecular Cancer

Figure 1

From: No effect of cancer-associated SNP rs6983267 in the 8q24 region on co-expression of MYC and TCF7L2 in normal colon tissue

Figure 1

Location of MYC and TCF7L2 expression assays. A. MYC exons and 5' and 3'untranslated regions (UTRs) are marked by rectangles and two translation starts are marked by vertical lines and arrows. MYC assay1 is located over the junction of exons 2 and 3, and MYC assay 2 is located over the junction of exons 1 and 2. MYC assay 3 targets alternative transcript with an upstream exon. B. Constitutive exons of TCF7L2 are represented as black rectangles and alternative exons as white rectangles. Protein domains are indicated above corresponding exons: β-catenin binding domain is encoded by exons 1 and 2, high mobility group (HMG) DNA-binding domain is encoded by exons 9 and 10 and the CRARF DNA-binding domain is encoded by exons 13 and 14. Location of expression assays is indicated under corresponding exons and arrows show primer positions. The specificity of detection of particular splicing forms is achieved by probes located over exon junctions.

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Molecular Cancer

ISSN: 1476-4598