Figure 7
From: A new synthetic protein, TAT-RH, inhibits tumor growth through the regulation of NFκB activity
Histological analysis of TAT-RH treated tumors. Control and treated tumors were analized by histology. A) To evaluate angiogenesis in these tumors, lectin staining was used to visualize microvessels. TAT-RH reduces the formation of tumor vasculature. B and C) Cell death and proliferation were evaluated by analysis of cleaved caspase 3 and PCNA levels. TAT-RH treated tumors show increased cleaved caspase 3 levels (B) and reduced cell proliferation (C). D) We also evaluated IκBα subcellular localization. IκBα mainly localizes in the cytosol in control tumors while TAT-RH treatment causes its nuclear accumulation.