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Figure 1 | Molecular Cancer

Figure 1

From: Insulin-like growth factor binding protein-3 has dual effects on gastrointestinal stromal tumor cell viability and sensitivity to the anti-tumor effects of imatinib mesylate in vitro

Figure 1

Imatinib-induced IGFBP3 expression is heterogenous in GIST cells. GIST882 (A) or GIST-T1 (D) cells were treated with different doses of imatinib for 24, 48, or 72 hours and then analyzed with the MTS assay to determine cell viability. After treatment with 1 μM imatinib for 24 or 48 hours, whole cell lysates isolated from GIST882 (B) or GIST-T1 (E) were analyzed for IGFBP3 expression by immunoblotting, or (C) conditioned medium from GIST882 cells analyzed for IGFBP3 levels by ELISA. rhIGFBP3, recombinant human IGFBP3.

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Molecular Cancer

ISSN: 1476-4598