Figure 7
From: MUC16 provides immune protection by inhibiting synapse formation between NK and ovarian tumor cells
csMUC16 inhibits NK activating synapse formation. A. NK cells from healthy donors were mixed with csMUC16neg-OVC and csMUC16pos-OVC cells and confocal microscopy was conducted using 10× magnification. White arrows indicate NK cells bound to tumor cells and some forming activating immune synapses. B. Immune synapses between the NK cells and csMUC16neg-OVC at 40× magnification are shown. NK cells are present in the vicinity of csMUC16pos-OVC cells but form significantly less conjugates and immune synapses. C. Immune synapses between NK cells from three healthy donors and the csMUC16neg-OVC or the csMUC16pos-OVC cells were quantified by counting conjugates that showed polarization of LFA-1 and CD2 divided by the total number of conjugates (defined as two cells in contact).