Figure 4
From: Characterization of bortezomib-adapted I-45 mesothelioma cells
ER stress activation and UPS induction. A: I-45 and I-45-BTZ-R cells were treated with 40 nM bortezomib for 24, 48, or 72 hours. Expression of Bip, CHOP, or HSP27 was analyzed by Western blot analysis. B: I-45 and I-45-BTZ-R cells were treated with 50,100, 200, or 400 nM bortezomib for 48 hours. Expression of Bip, CHOP, or noxa, and cleavage of caspase-3 and PARP was analyzed by Western blot analysis.