NOTCH2 in breast cancer: association of SNP rs11249433 with gene expression in ER-positive breast tumors without TP53 mutations

Table 1 Results of microarray analysis for 5 genes within 1 Mb from rs11249433 in the 1p11.2 region.

Gene/SNP	Position, bp⁺	rs11249433	N	Fold*	95%CI	p-value*
ADAM30	chr1: 120,237,679 - 120,240,636	AA	35	1.00	0.90 - 1.11	0.378
		AG	41	1.06	0.96 - 1.16
		GG	13	0.93	0.80 - 1.09
NOTCH2	chr1: 120,279,260 - 120,413,799	AA	41	1.00	0.85 - 1.18	0.054
		AG	45	1.28	1.10 - 1.50
		GG	17	1.16	0.91 - 1.46
NOTCH2NL	chr1: 120,338,694 - 120,398-362	AA	41	1.00	0.75 - 1.33	0.038
	chr1: 143,920,468 - 144,009,723	AG	47	0.64	0.49 - 0.83
		GG	19	0.70	0.47 - 1.04
FAM72B	chr1: 120,640,935 - 120,657,204	AA	41	1.00	0.68 - 1.47	0.218
		AG	47	0.76	0.53 - 1.10
		GG	19	0.59	0.35 - 1.00
SRGAP2	chr1: 120,808,675 - 120,832,674	AA	41	1.00	0.82 - 1.21	0.652
	chr1: 204,582,823 - 204,648,014	AG	48	1.03	0.86 - 1.24
		GG	19	0.89	0.68 - 1.17
rs11249433	chr1: 120,982,136

ISSN: 1476-4598