Figure 5From: Determination of genes and microRNAs involved in the resistance to fludarabine in vivo in chronic lymphocytic leukemiaRelationship between gene expression before treatment and sensitivity to fludarabine in CLL patients. Expression levels of the targets were investigated by RT-qPCR and normalized to both housekeeping genes. The average expression level in sensitive patients was used as calibrator. Expression levels presented as mean values ±SEM were investigated on two groups of CLL patients; eighteen patients in vivo (8S and 10R) and twenty-one patients in vitro (16S and 5R). Statistical analysis was performed by 2-sided t-test and levels were considered to be significantly different when p values were lower than 0.05. A and B. The expression of MYC and SULF2 was measured in CLL B cells of patients before their treatment with fludarabine in vivo (A) and in vitro (B). C and D. The expression of miR-29a, miR-181a, and miR-221 was investigated in CLL B cells of patients before their treatment with fludarabine in vivo (C) and in vitro (D).Back to article page