Figure 1
From: Activation of HER family members in gastric carcinoma cells mediates resistance to MET inhibition
Activation of HER family members rescues PHA-impaired cell viability and growth. (A,C) Viability assays. GTL16 cells were untreated (NT) or treated with the PHA (250 nM), in the indicated conditions (EGF 50 ng/ml, HRG1-β1 10 ng/ml, or Gefitinib 250 nM). MET inhibition led to a strong decrease in cell viability compared to untreated cells (considered as 100%). Activation of HER members, upon EGF or HRG1-β1stimulation, conferred resistance to MET inhibition (*** P < 0,001). The specificity of the effect is shown by its loss in the presence of Gefitinib. (B,D) Growth curves. GTL16 cells were either untreated (NT) or treated with the indicated molecules. The block of cell growth induced by PHA was overcome by EGF or HRG1-β1 stimulation (** P < 0,01).