Differential expression of p53-pathway genes in sensitive and refractory CLLs. (A) Cellular representation of BioCarta p53 signaling pathway. Genes involved in p53 pathway were colored in accordance to microarray expression data for post CLLs normalized on matched pre samples. Average expression in CR patients is on the right part of the colorbar, NR patients on the left part. Genes like p21, GADD45A, PCNA are up-modulated only in sensitive CLLs. (B) Average expression of all the genes involved in p53 pathways (cell cycle control and apoptosis) in pre/post CR and pre/post NR groups. Puma/BBC3 gene is induced only in sensitive CLLs.