Skip to main content

Table 1 FANCD2- and RAD51-nuclear focus formation in 48 GI cancer cell lines

From: Genetic inactivation of the Fanconi anemia gene FANCC identified in the hepatocellular carcinoma cell line HuH-7 confers sensitivity towards DNA-interstrand crosslinking agents

Cell line

Cancer type

FANCD2

RAD51

Cell line

Cancer type

FANCD2

RAD51

AGS

gastric

+

+

L3.6pl

pancreatic

+

+

AsPC-1

pancreatic

+

+

LoVo

colorectal

+

+

AZ-521

gastric

+

+

LS1034

colorectal

+

+

BxPC-3

pancreatic

+

+

LS513

colorectal

+

+

Caco-2

colorectal

+

+

MIA PaCa-2

pancreatic

+

+

Capan-1

pancreatic

+

-

MKN 45

gastric

+

+

Capan-2

pancreatic

+

+

MKN 7

gastric

+

+

CFPAC-1

pancreatic

+

+

NCI-N87

gastric

+

+

Chang

hepatocellular

+

+

PANC-1

pancreatic

+

+

CoGa 12

colorectal

+

+

PL11

pancreatic

-

+

CoGa 5

colorectal

+

+

PL3

pancreatic

+

+

CoGa 5L

colorectal

+

+

PL45

pancreatic

+

+

Colo 320

colorectal

+

+

PL5

pancreatic

+

+

DLD-1

colorectal

+

+

PL8

pancreatic

+

+

EGI-1

cholangiocellular

+

+

PLCPRF5

hepatocellular

+

+

HCA-7

colorectal

+

+

SNU-1

gastric

+

+

HCT 116

colorectal

+

+

SNU-5

gastric

+

+

Hep3B

hepatocellular

+

+

SU.86.86

pancreatic

+

+

HepG2

hepatocellular

+

+

SW48

colorectal

+

+

Hs766T

pancreatic

-

+

SW480

colorectal

+

+

HT-29

colorectal

+

+

SW620

colorectal

+

+

HuH-7

hepatocellular

-

+

SW948

colorectal

+

+

Isreco 1

colorectal

+

+

TFK-1

cholangiocellular

+

+

KATO III

gastric

+

+

WiDr

colorectal

+

+

  1. (+) detectable or (-) no detectable nuclear focus formation of FANCD2 or RAD51, respectively, in the indicated cell lines, 6 h after treatment with IR at 15 Gy. FA pathway-deficient cell lines are depicted in bold.