VHZ is elevated in a significant fraction of several types of human cancers. A. VHZ-positive signals (DAB chromogen in brown) were mainly detected at the plasma membrane, cytosol, and the Golgi-like sub-cellular structures in the cytoplasm. VHZ overexpression was closely associated with squamous cell carcinoma in the lung, bladder, esophagus, skin, lip, larynx, vulva, cervix, and penis etc. Selected VHZ-positive cancer samples from the colon (a, ×400), lung (b, ×400), esophagus (c, ×400), stomach (d, ×400), lip (e, ×200), and skin (f, ×200) were shown. B. VHZ protein expresses in multiple human cancers. Percentages of VHZ positive cancers were summarized from a total of 448 human cancer samples. VHZ enhanced MCF-7 cells migration (S. Figure 2B). * Squamous cell carcinoma such as lip, larynx, vulva, cervix, penis etc.