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Table 3 Gene ontology of common down-regulated genes.

From: Gene expression profiling of cholangiocarcinoma-derived fibroblast reveals alterations related to tumor progression and indicates periostin as a poor prognostic marker

Gene ontology (%) Accession no. Description Ratio
Cellular metabolism (31.6%) NM_030965 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 3943.41
  NM_022969 fibroblast growth factor receptor 2 684.03
  AU152837 Sal-like 1 (Drosophila) 312.29
  NM_007287 membrane metallo-endopeptidase 73.38
  BF589322 R-spondin 3 homolog (Xenopus laevis) 70.16
Signal transduction (17.8%) NM_001200 bone morphogenetic protein 2 68.96
  NM_000710 bradykinin receptor B1 48.96
  R72286 microfibrillar-associated protein 4 32.40
  NM_004114 fibroblast growth factor 13 28.15
  BE218107 EPH receptor A5 25.68
Transcription factor (11.5%) AJ277914 LIM homeobox 9 25.01
  NM_001452 forkhead box F2 18.08
  AA705845 transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) 17.16
  BG261252 ecotropic viral integration site 1 11.58
  NM_020327 activin A receptor, type IB 9.32
Protein modification (7.9%) AF245505 matrix-remodelling associated 5 57.89
  AA725644 ubiquitin specific peptidase 42 18.73
  NM_001982 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 11.34
  AV727260 protein tyrosine phosphatase, receptor type, D 10.93
  NM_002570 proprotein convertase subtilisin/kexin type 6 9.83
Cell differentiation (6.2%) NM_000641 interleukin 11 17.51
  BC006454 growth arrest-specific 7 15.20
  M69148 midkine (neurite growth-promoting factor 2) 14.03
  NM_003991 endothelin receptor type B 10.85
  AI758962 EPH receptor A4 7.15
Cell adhesion (5.9%) NM_001999 fibrillin 2 1035.17
  NM_014893 neuroligin 4, Y-linked 68.62
  AI694562 collagen, type IV, alpha 3 22.21
  NM_005864 embryonal Fyn-associated substrate 8.44
  AU146651 collagen, type XII, alpha 1 4.89
Cell cycle (5.9%) NM_014059 chromosome 13 open reading frame 15 28.40
  M19701 retinoblastoma 1 (including osteosarcoma) 4.93
  NM_002009 fibroblast growth factor 7 4.44
  NM_014703 Vpr (HIV-1) binding protein 3.92
  AI983033 DEAD/H box polypeptide 12 3.91
Cell motility (4.7%) NM_002784 pregnancy specific beta-1-glycoprotein 9 69.22
  X99268 twist homolog 1 5.45
  NM_015180 spectrin repeat containing, nuclear envelope 2 3.81
  AI990816 laminin, alpha 1 3.59
  N90777 neuropilin 2 3.57
Cell proliferation (4.5%) NM_016931 NADPH oxidase 4 5.79
  AF064826 glypican 4 4.31
  NM_004525 low density lipoprotein-related protein 2 3.85
  NM_001963 epidermal growth factor (beta-urogastrone) 3.70
  AF064103 CDC14 cell division cycle 14 homolog A 3.67
Apoptosis (4.0%) NM_006850 interleukin 24 25.27
  NM_002135 nuclear receptor subfamily 4, group A, member 1 5.48
  NM_003823 tumor necrosis factor receptor superfamily 4.59
  AJ301610 glutamate receptor, ionotropic, kainate 2 3.92
  NM_005809 peroxiredoxin 2 3.90
  1. Only genes in the top-five ranking of each group are shown.