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Figure 3 | Molecular Cancer

Figure 3

From: Complement activation mediates cetuximab inhibition of non-small cell lung cancer tumor growth in vivo

Figure 3

Complement activation by cetuximab in lung cancer cells. A, Deposition of C3-related fragments and C5b-C9 on A549 cells after incubation with NHS and cetuximab was determined by flow cytometry. Incubation with a human IgG1 isotype control was used as control. Data were collected as mean fluorescence intensity and the graphs show mean + SEM (*, p < 0.05). B and C, Complement-mediated cell death in A549 (B) and H187 (C) cells treated with cetuximab (40 μg/ml) and evaluated by flow cytometry. Data were collected as percentage of DNA fragmentation and the graph shows mean + SEM (*, P < 0.05; n.s., non-significant).

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Molecular Cancer

ISSN: 1476-4598