Figure 4
From: Deletion analysis of BMI1 oncoprotein identifies its negative regulatory domain
The ∆PS mutant of BMI1 promotes invasion and migration. (A) MCF10A-B0, MCF10A-BMI1WT and MCF10A-BMI1∆PS were analyzed for invasion potential using 24-well BD Biocoat Matrigel Invasion Chambers (BD Biosciences, San Jose, CA) as described in the Materials and Methods section. The columns represent mean value of triplicate samples and bars represent SD. (B). The migration potential of MCF10A-derived cells was determined using a wound healing assay as described in the Materials and Methods section.