ROS accumulation and IGF-IR inhibition contribute to fenofibrate/PPARα -mediated inhibition of Glioma cell motility in vitro

Table 2 Analyses of Glioma Individual Cell Displacement.

Conditions\Parameters	Total length of cell trajectory (μm)	Average speed of cell movement (μm/min)^a	Length of final cell displacement (μm)	Average rate of cell displacement (μm/min) ^b	Coefficient of movement efficiency (CME) ^c
FBS	206.3 ± 4.6	0.34 ± 0.07	192.99 ± 5.30	0.32 ± 0.008	0.83 ± 0.04
FBS + FF	83.30 ± 2.6*	0.14 ± 0.05*	58.12 ± 2.10*	0.09 ± 0.003*	0.45 ± 0.02*
FBS + NVP	217.03 ± 6	0.36 ± 0.009	201.31 ± 6.61	0.33 ± 0.01	0.8 ± 0.01
FBS + FF + NAC	132.4 ± 3.4	0.22 ± 0.005	67.7 ± 2.8	0.11 ± 0.005	0.51 ± 0.02

Individual tracks of T98G cell locomotion were generated by determination of cell centroid displacements with time-lapse images taken at 20 minutes intervals during a total observation period of 10 hours. All experimental parameters are identical to those described in the legend to Table 1. The values are given as the mean +/-SEM (n = 50). * Statistically different from FBS at p≤0.05. ** Statistically different from SFM at p≤0.05.

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