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Figure 3 | Molecular Cancer

Figure 3

From: Dasatinib reverses Cancer-associated Fibroblasts (CAFs) from primary Lung Carcinomas to a Phenotype comparable to that of normal Fibroblasts

Figure 3

Relationship of Dasatinib regulated genes with functional datasets resembling quiescence [24]and normal fibroblasts [26]. A, Venn diagrams depicting the number of genes differentially regulated by Dasatinib only, by Dasatinib and serum, and by serum only (upper panel). Both the overlap of genes downregulated and upregulated in both datasets is highly significant (p = 1.5 × 10-17 and p = 2.0 × 10-12; Fisher's exact test). The lower panel represents the heatmap of the overlap between Dasatinib regulated genes and core serum response genes. B, Venn diagrams depicting the number of genes regulated by Dasatinib only, differentially expressed in CAFs in absence or presence of Dasatinib and in CAFs vs. NAFs, and genes differentially expressed in CAFs vs. NAFs only (upper panel). The overlap of genes downregulated and upregulated in both datasets is highly significant (p = 6.6 × 10-30 and p = 2.3 × 10-11; Fisher's exact test). Heatmap of expression patterns of Dasatinib regulated genes overlapping with genes differentially regulated in CAFs vs. NAFs (lower panel).

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Molecular Cancer

ISSN: 1476-4598