Figure 1From: CXCR4/SDF1 mediate hypoxia induced chondrosarcoma cell invasion through ERK signaling and increased MMP1 expressionExpression of CXCR4 and SDF-1 in normal cartilage (CL) and chondrosarcoma tissue (CS). A and B, the endogenous mRNA levels of CXCR4 and SDF-1were quantified by qRT-PCR and normalized to 18S. Graphs represent the median of CXCR4 and SDF-1 levels with the 25th-75th percentiles, *, p < 0.001, CS (n = 16) versus CL (control, n = 8). C, CXCR4 protein level in CL and CS. Whole cell lysates from two CL and three CS specimens were subject to Western blot to detect CXCR4 protein. Representative blot is shown from one of three independent experiments. Actin was used as the loading control.Back to article page