Molecular Cancer

Table 1 RB1 alterations observed among patients included in the study

From: Identification and characterization of retinoblastoma gene mutations disturbing apoptosis in human breast cancers

Patient¹	Alterations in *RB1*		Response⁴
	Large rearrangements²	Point Mutations³
Dox19	AI	WT	PD
FUMI 12	AI	WT	PD
Dox 95	Del exon 13-27	WT	PD
FUMI 07	Del exon 21-23	Leu607Ile	PD
Dox 48	Duplication	WT	PD
Dox 65	WT	Arg621Cys (G.l)	PD
FUMI 39	Duplication	WT	SD
Dox 04	AI	WT	SD
Dox 32	AI	WT	SD
Dox 74	AI	WT	SD
Dox 83	AI	WT	SD
FUMI 25	AI	WT	SD
FUMI 26	AI	WT	SD
FUMI 27	AI	WT	SD
FUMI 44	AI	WT	SD
Dox 15	AI	WT	PR
Dox 109	AI	WT	PR
FUMI 15	AI	WT	PR
FUMI 23	AI	WT	PR
FUMI 29	AI	WT	PR
FUMI 37	AI	WT	PR
Dox 111	AI	Arg698Trp	PR
Dox 39	Duplication	WT	PR
FUMI 30	AI	WT	NE

¹ Dox "X", patients treated with doxorubicin; FUMI "X", patients treated with FUMI.
²AI, allelic imbalance; Del, deletion; WT, wild-type. ³G.l, germline. ⁴ PD, progressive disease; SD, stable disease; PR, partial response; NE, not evaluable.

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ISSN: 1476-4598

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