E-cadherin expression is increased in metastases compared to primary tumors. A) Percentage of E-cadherin-positve cells is increased in metastases compared to the primary tumors. Organ sites of metastases are organized by color: liver (red), lung (blue), and brain (yellow) B) Example of a case showing strong expression of E-cadherin in the metastasis (right) compared to negative expression in primary (left). C) Heterogeneous expression of E-cadherin in the center (dashed inset) versus edge (solid inset) of a liver metastasis. "C" denotes tumor and "H" denotes hepatocytes. D) Quantification of E-cadherin staining in the center and edge of the liver metastasis.