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Table 2 ALK fusion variants previously reported in lung cancer.

From: Fusion of EML4 and ALK is associated with development of lung adenocarcinomas lacking EGFR and KRAS mutations and is correlated with ALK expression

Citation

Freq.

Origin

Method

Number of Positives for each Fusion type

    

V1

V2

V3

V4

V5

V6

V7

V8

V9

Soda, et al. Nature 2007

6.7%

(5/75)

Japanese

RT-PCR

3

2

       

Takeuchi et al.

Clin Cancer Res. 2008

4.35%

(11/253)

Japanese

RT-PCR

3

3

3

1

1

    

Takeuchi et al.

Clin Cancer Res. 2009

/

Japanese

iAEP/RT-PCR

1

1

3

  

1

1

  

Koivunen et al.

Clin Cancer Res. 2008

3.6% (6/167)

Korean

RT-PCR

2

 

4

    

2

 
 

1.4% (2/136)

Caucasian

          

Inamura et al. J Thorac Oncol. 2008

2.3% (5/221)

Japanese

RT-PCR

2

3

       

Perner et al. Neoplasia 2008

0.5% (3/603)

Caucasian

FISH, RT-PCR

3

        

Wong et al.

Cancer. 2009

4.9% (13/266)

Chinese

RT-PCR

2

2

8

     

1

Martelli et al.

Am J Pathol. 2009

7.5% (9/120)

Italian and Spanish

RT-PCR

7

 

2

      

Present study

11.6%

(12/103)

Chinese

RACE-coupled PCR sequenc-ing

4

1

3

 

1

   

3

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Molecular Cancer

ISSN: 1476-4598