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Figure 11 | Molecular Cancer

Figure 11

From: The dietary isothiocyanate sulforaphane modulates gene expression and alternative gene splicing in a PTEN null preclinical murine model of prostate cancer

Figure 11

Comparison of gene changes in PTEN null mice on different diets compared to WT mice fed the control diet. Overlap of differentially expressed transcripts (P ≤ 0.05) of 8-week old PTEN null mice on the control diet (989 transcripts, 'PTEN signature transcripts', Table 1), low sulforaphane (LSF, 1718 transcripts, Table 1) and high sulforaphane (HSF, 2390 transcripts, Table 1) diet each compared to 8-week old WT mice on the control diet. A, Functional analysis by GenMAPP of these genes (data not shown) confirmed that they are enriched for genes involved in immune response, inflammatory response and response to wounding, two of which are common pathways between all three diets (Table 3). B, Details of these genes are shown in Additional file 3 - Table S3. C, Functional analysis of these genes is shown in Additional file 4 - Table S4.

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Molecular Cancer

ISSN: 1476-4598