Figure 4

Overlapping of mouse and human tumors. (a) Gene expression overlapping between mouse tumors and human samples with TP53 mutations from 7 different cancer types is shown. n: total number of human tumors analyzed. Bar plots represent the significance of the overlap between overexpressed genes in tumors of p53-deficient mouse and genes overexpressed in human tumor samples with TP53 mutations (p-val, Fisher's exact test). Numbers at left represent the gene number overlap. Aside the plot is represented the color codes for each cancer tissue. Asterisk represents the most significant overlapping. (b) Mouse tumors as models for missense and truncating TP53 mutations. Gene expression values of the 98 genes overlapping between the mouse tumors and the breast cancer samples from Ivshina et al. [26] (asterisk in panel a) with TP53 mutations (overlapping score; mean = 0, stdv = 1) were plotted depending on the TP53 mutation status (left) or the mutation type (right). Number of tumor samples and significance of mean difference is shown. (c) Gene expression overlapping between mouse tumors and human samples with poor outcome from 11 different cancer types is shown. n: total number of human tumors analyzed. Bar plots represent the significance of the overlap between overexpressed genes in tumors of p53-deficient mouse and genes overexpressed in human tumor samples with poor outcome (p-val, Fisher's exact test). Numbers at left represent the gene number overlap. Aside the plot is represented the color codes for each cancer tissue.