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Figure 4 | Molecular Cancer

Figure 4

From: A yeast-based genomic strategy highlights the cell protein networks altered by FTase inhibitor peptidomimetics

Figure 4

Multidrug transporter GFP-Pdr5 recycling is affected by FTI treatment of wt cells. A, fluorescence (upper panels) and DIC (lower panels) images of K699 cells expressing Alr1-GFP or Gap1-GFP proteins. B, Representative fluorescence images of cells expressing PDR5-GFP with plasma membrane (PM) or endosomal (END) localization are shown in the right panels. Images were taken in a blind fashion at time 0 h (T0) or 2 h (T2 h) after 10 μM FTase inhibitor addition and at least 100 cells were counted per sample. The graph on the left represents the increase (%) of END-type over PM-type cells observed in FTI-treated versus untreated cells. The values are the mean of 3 independent experiments. Bar indicates standard deviation. 10 μM FTase inhibitor I (+FTI); untreated (NT).

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Molecular Cancer

ISSN: 1476-4598