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Figure 2 | Molecular Cancer

Figure 2

From: TRAIL sensitize MDR cells to MDR-related drugs by down-regulation of P-glycoprotein through inhibition of DNA-PKcs/Akt/GSK-3β pathway and activation of caspases

Figure 2

Sensitization of MDR cells to TRAIL is mediated through caspase-dependent mitochondrial apoptotic pathway. The cell lysates obtained from CEM or CEM/VLB100 cells after exposure to graded doses of TRAIL (1~10 ng/ml) for 24 h were subjected to western blot analysis to monitor levels of caspase-8, -10, -9 and -3, Bid, truncated Bid (tBid), Bax and Bcl-2. The levels of PARP and its cleavage fragment (CF) in TRAIL-treated cells were also determined.

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Molecular Cancer

ISSN: 1476-4598