Skip to main content
Figure 3 | Molecular Cancer

Figure 3

From: TRAIL sensitize MDR cells to MDR-related drugs by down-regulation of P-glycoprotein through inhibition of DNA-PKcs/Akt/GSK-3β pathway and activation of caspases

Figure 3

Expression of p-gp in MDR cells is associated with the enhanced expression of c-Myc and DR5 and activation of DNA-PKcs/Akt/GSK-3β pathway. The protein levels of P-gp, c-Myc, DNA-PKcs, pAkt, GSK-3β, phosphorylated Akt (pAkt) at Ser 473, total Akt (tAkt), phosphorylated GSK-3β (pSK3β) at Ser9, total GSK-3α/β, DR4 and DR5 were determined by western analysis. Actin was used as a loading control.

Back to article page

Molecular Cancer

ISSN: 1476-4598