Figure 7From: MiTF links Erk1/2 kinase and p21CIP1/WAF1 activation after UVC radiation in normal human melanocytes and melanoma cellsMiTF mediates signal transduction from Erk1/2 to p21WAF1/CIP1 after UVC and ROS stress. UVC and ROS trigger Erk1/2 activation, which leads to MiTF phosphorylation and degradation, and enables a temporary G1 cell cycle arrest and subsequent cell survival.Back to article page