Table 2 The effect of FLLL32 on human protein and lipid kinases using a kinase profile assay.
Protein Kinases | IC50 (μM) | |
|---|---|---|
Tyrosine kinases contain SH2 Domain | JAK3 | >100 |
Lck | >100 | |
Syk | >100 | |
ZAP-70 | >100 | |
TYK2 | >100 | |
Tyrosine kinases containSH2 and SH3 Domains | Abl-1 | >100 |
BTK | >100 | |
Lyn | >100 | |
Yes | >100 | |
Other human protein or lipid kinases | AKT1 | >100 |
CDK4/CyclinD1 | >100 | |
FAK | >100 | |
JNK1-α1 | >100 | |
MEK1 | >100 | |
mTOR | >100 | |
PI3K (P110α/85α) | 63.23 | |
PI3K (P110β/85α) | 57.33 | |
PKA | >100 | |
PKCα | >100 | |
PKC-γ | >100 |