Potential nuclear and cytoplasmic functions of PRAME. Schematic representation depicting interactions of PRAME with nuclear proteins such as retinoic acid receptor (RAR), polycomb repressor EZH2 and the serine threonine kinase STK19. Interaction with RARs and EZH2 is thought to modulate gene expression and responses to retinoic acid signalling. PRAME also interacts with the outer membrane opacity protein (OPA-P) from bacterial pathogen N. gonorrhoea, and may also interact with other pathogen-associated microbial patterns (PAMPs) entering the cytoplasm. In addition, expression of PRAME in cancer cells may allow it to function in sensing molecules associated with cancer or cancer-related inflammation.