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Figure 2 | Molecular Cancer

Figure 2

From: Dissecting the roles of DR4, DR5 and c-FLIP in the regulation of Geranylgeranyltransferase I inhibition-mediated augmentation of TRAIL-induced apoptosis

Figure 2

GGTI-298 modulates the levels of DR4, DR5, c-FLIP, p-Akt and survivin in human NSCLC cells. A, The given cell lines were treated with 15 μM GGTI-298 for 16 h. B, A549 cells were treated with the indicated concentrations of GTI-298 for 16 h. C, A549 cells were treated with 15 μM GGTI-298 for the given times. After the aforementioned treatments, the cells were subjected to preparation of whole-cell protein lysates and subsequent Western blotting. LE, longer exposure; UP, unprenylated.

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Molecular Cancer

ISSN: 1476-4598