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Figure 3 | Molecular Cancer

Figure 3

From: Dissecting the roles of DR4, DR5 and c-FLIP in the regulation of Geranylgeranyltransferase I inhibition-mediated augmentation of TRAIL-induced apoptosis

Figure 3

RhoB is upregulationed by GGTI-298 (A) and in part mediates DR5 upregulation by GGTI-298 (B). A, A549 cells were treated with 15 μM GGTI-298 for the given times and then subjected to preparation of whole-cell protein lysates and subsequent Western blotting. B, A549 cells were cultured in a 6-well plate and the next day transfected with the indicated siRNAs. After 36 h, the cells were treated with 15 μM GGTI-298 for 12 h and then subjected to preparation of whole-cell protein lysates for Western blotting. Ctrl, control; LE, longer exposure.

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Molecular Cancer

ISSN: 1476-4598