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Figure 5 | Molecular Cancer

Figure 5

From: Dissecting the roles of DR4, DR5 and c-FLIP in the regulation of Geranylgeranyltransferase I inhibition-mediated augmentation of TRAIL-induced apoptosis

Figure 5

Enforced expression of ectopic FLIP S attenuates the effects of the GGTI-298 and TRAIL combination on decreasing cell survival ( A ) and inducing apoptosis ( B ). A, The indicated transfectants were seeded in 96-well plates and treated with the indicated concentrations of GGTI-298 plus 20 ng/ml TRAIL. After 24 h, the cells were subjected to the SRB assay for measurement of cell number. Data are means of four replicate determinations. Bars, ± SDs. B, The indicated transfectants were treated with DMSO, 15 μM GGTI-298, 20 ng/ml TRAIL, and the combination of GGTI-298 and TRAIL for 24 h and then subjected to detection of apoptosis by Annexin V staining. GGTI, GGTI-298.

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Molecular Cancer

ISSN: 1476-4598