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Figure 2 | Molecular Cancer

Figure 2

From: Cooperative and individualistic functions of the microRNAs in the miR-23a~27a~24-2 cluster and its implication in human diseases

Figure 2

Role of hsa-miR-23a in various pathological conditions. During cancer, repression of miR-23a by MYC leads to up-regulation of glutaminase (GLS) thus mediating glutamine metabolism which is important for bioenergetics and maintaining redox homeostasis in cancer cells. The transcription factor NFATc3 induces miR-23a which down-regulates MURF1, an anti-hypertrophic protein leading to cardiac hypertrophy. Also, in the conditions of heat induced stress, the expression level of miR-23a increases and by down-regulating MAFbx (an atrophic factor), it provides resistance to muscle atrophy.

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Molecular Cancer

ISSN: 1476-4598